Our Providers
W. Angus Muir, MD, PhD

 

Office Location(s):

Hematology-Oncology Associates of Fredericksburg


4501 Empire Court
Fredericksburg, Virginia   22408
Location Phone: 540-371-0079

My Phone: 540.371.0079
Fax: 540.371.4254

Accepting new patients:
I am accepting new patients.

Undergraduate Education:
B.S., George Washington University : 1960


Medical Education:
M.D., Case Western Reserve University : 1970


Ph.D., University of Rochester School of Medicine, Department of Anatomy (Human Genetics) : 1966


M.S., George Washington University, Department of Anatomy : 1962


Residency:
Resident in Hematology, Case Western Reserve University : 1973


Resident in Medicine, Case Western Reserve University : 1972


Fellowship:
Hematology-Oncology Fellowship : 1973-1974
Case Western Reserve University

Post-Doctoral Fellowship in Human Genetics : 1966-1968
Case Western Reserve University, Department of Biology under Dr. Arther G. Steinberg

Academic Appointments:
Associate Professor of Medicine : 1985
Case Western Reserve University.

Associate Professor of Biology : 1982-1985
Case Western Reserve University.

Director : 1976-1983
Case Western Reserve Genetics Center

Associate Professor of Medicine : 1974-1985
Department of Medicine, Case Western Reserve University

Director : 1974-1985
Division of Human Genetics, Department of Medicine, Case Western Reserve University.

In Practice Since:
1988

Affiliations:
Co-Director Inpatient Palliative Medicine Unit, Mary Washington Hospital : 2000


Sigma Xi


American Society of Hematology


American Society for the Advancement of Science


Consultant, NIH Committee on Genetics of Common Diseases, 1978-79.


Member Southeastern Oncology Group (SEG)


American Society of Human Genetics
American Federation of Clinical Research


Publications:
Publication : 1984
Muir, W.A., Beutler, E., Wasson, C.: Pyruvate kinase deficiency in the Ohio Amish. Am J Hum Gen 36: 634-639, 1984.

Publication : 1984
Muir, W.A., Hedrick, S., Alper, C., Ratnoff, D.D., Schacter, B., Wisnieski, J.:  Inherited incomplete deficiency of the fourth component of complement (C4) determined by a gene not linked to HLA. J Clin Invest 74: 1509-1514, 1984.

Publication : 1984
Muir, W.A., Hopfer, U., King, M.: Iron transport across brush border membranes from normal and iron deficient mouse upper small intestine. J Biol Chem 259: 4896-4903, 1984.

Publication : 1984
Klinger, K.W., Muir, W.A., Gilliam, C.: A random chromosome 6 DNA probe and RFLP analysis of HLA-typed families. ICSU Short Reports 1:190-191, 1984.

Publication : 1984
Muir, W.A., McLaren, G.D., Braun, W., Askari, A.: Evidence of heterogeneity in hereditary hemochromatosis. Evaluation of 174 individuals in 9 families. Am J Med 76: 806-814, 1984.



Publication : 1983
Nathanson, M.H., McLaren, G.D., and Muir, W.A.: Regulation of iron absorption in normal and iron-deficient beagle dogs: Mathematical compartment modeling of mucosal iron kinetics. 1983, Elsevier Publishers: B.V. Structures and Function of Iron Storage and Transport Proteins, I. Urushizak et a1 eds. pg. 409-412.

Abstract : 1983
Nathanson, M.H., McLaren, G.D., Seidel, G.M.,and Muir, W.A.: In vivo characterization of iron absorption by compartmental analysis. Fed. Proc., in press. Presented at the 67th Annual Meeting, April 10-15, 1983, Chicago, Illinois.

Chapter in book : 1983
Sachs, D.P.L., Supinski, G., Muir, W.A.: Genetic Pulmonary Disease: Pulmonary Parenchyma. In Textbook of Pulmonary Diseases, 3rd Edition.  Baum, G. (Ed.) 1983.

Publication : 1983
McLaren, G.D., Muir, W.A., and Kellermeyer, R.W.: Hemochromatosis: Clinical, Pathological, and Pathogenetic Considerations. CRC Crit Rev Clin Lab Sci 19: 205-266, 1983.

Publication : 1983
Muir, W.A ., Knoke, J., Martin, A., Vignos, P., McErlean, A.: Improved detection of Duchenne muscular dystrophy heterozygotes using discriminant analysis of creatine kinase levels. Am J Med Genet 14: 125-34, 1983.

Publication : 1983
Askari, A. D., Muir, W.A ., Rosner, I.A., Moskowitz, R.W., McLaren, G.D., Braun, W.E.: Arthritis of hemochromatosis: Clinical spectrum, relation to histocompatibility antigens and effectiveness of early phlebotomy. Am J Med 75: 957-965, 1983.

Publication : 1982
Bittenham, G.M., Farrell, D.E., Harris, J.W., Feldman, E.S., Danish, E.H., Muir, W.A ., Tripp, J.H., and Bellon, E.M.: Magnetic susceptibility measurement of human iron stores. N Engl J Med 307: 1671-1675, 1982.

Abstract : 1982
Blumer, J., Frank, D.M., Dunn, R., and Muir, W.A.: Genetics of eryl hydrocarbon hydroxylase (AHH) inducibility in acute lymphocytic leukemia of childhood (ALL). American Society of Human Genetics, 1982.

Publication : 1982
Ransohoff, D.F., and Muir, W.A.: Diagnostic workup bias in the evaluation of a test: Serum ferritin and hereditary hemochromatosis. Med Decis Making 2: 139-145, 1982.

Publication : 1981
Farrell, D.E., Tripp, J.H., Zanzucchi, P.E., Harris, J.W., Brittenham, G.M., Bellon, E.M., and Muir, W.A.: An application of Superconductivity to medical diagnostics. Appl Physics Comm 1:1- , 1981.

Publication : 1981
Rosner, I.A., Askari, A.D., McLaren, G.D., Muir, W.A.: Arthropaty, hypouricemia and normal serum iron studies in hereditary hemochromatosis. Am J Med 70: 870-874, 1981.

Publication : 1981
Goldsmith, G.H., Saito, H., Muir, W.A.: Labile anticoagulant in a patient with lymphoma. Am J Hematol 10: 305-311, 1981.

Publication : 1981
Farrell, D.E., Tripp, J.H., Zanzucchi, P.E., Harris, J.W., Brittenham, G.M., Muir, W.A.: Non-invasive SQUID diagnosis of liver iron overload. Biomagnetism. Erne, S.N., and Hahlbohm, H.D. (eds). Walter deGrayter, Berlin, 1981, pp. 507-518.

Abstract : 1980
Brittenham, G.H., Zanzucchi, P.E., Ferrell, D.E., Tripp, J.H., Muir, W.A., Harris, J.W.: Non-invasive  in vivo measurement of human iron overload by magnetic susceptibility studies. Clin Res 28: 546A, 1980.

Publication : 1980
Hazen, P.G., Muir, W.A., Zomura, I., Bruner, W.E.: Premature cataracts in a family with hidrotic ectodermal dysplasia. Arch Dermatol 116: 1385- 1387, 1980.

Publication : 1980
Brittenham, G.M., Zanzucchi, P.E., Farrell, D.E., Tripp, J.H., Muir, W.A., Harris, J.W. : Non-invasive in vivo measurement of human iron overload by magnetic susceptibility studies. Trans Assoc Am Phys 93: 156-163, 1980.

Publication : 1980
Cowchock, S., Ainbender, E., Prescott, G., Crandell,  B., Lau, L., Muir, W.A., Kloza, E., Feigelson, M., Mennuti, M., Cederquist, L.: The recurrence risk for neural tube defects in the United States: A
collaborative study. Am J Med Genet 5:309-314, 1980.

Publication : 1980
Kurczynski, T.W., Muir, W.A., Palomaki, J., Gaull, G.E.: Maternal homocystinuria: Studies of an untreated mother and fetus. Arch Dis Child 55: 721-723. 1980.

Publication : 1980
Goodnough, L.T, and Muir, W.A.: Bullous pemphigoid as a manifestation of chronic lymphocytic leukemia. Arch Intern Med 140: 1526-1527, 1980.

Publication : 1980
Farrell, D.E., Tripp, J.H., Zanzucchi, P.E., Harris, J.W., Brittenham, G.M., Muir, W.A.:  Magnetic measurement of human iron stores. Proceedings, International Magnetics Conference, 1980. IEEE Transactions on Magnetics 16: 818-823, 1980.

Abstract : 1980
Farrell, D.E., Tripp, J.H., Zanzucchi, P.E., Harris, J.W., Brittenham, G.M., and Muir, W.A.: Non-invasive SQUID diagnosis or liver iron overload. Proceedings of the 2nd International Conference on Superconducting Quantum Interference Devices. Berlin, 1980.

Abstract : 1980
Farrell, D.E., Tripp, J.H., Zanzucchi, P.E., Harris, J.W., Brittenham, G.M., Muir, W.A.: Magnetic measurement of human iron stores. (Abstract). International Magnetics Conference, Boston, Mass., 1980.

Publication : 1979
Firshein, S.I., Hoyer, L.W., Lazarchick, J., Forget, B.G., Hobbins, J.C., Clyne, L.P., Pitlick, F.A., Muir, W.A., Merkatz, I.R. and Mahoney, M.J.: Prenatal diagnosis of classic hemophilia A. N Engl J Med 300: 937-941, 1979.

Publication : 1979
Rassin, D.K., Fleisher, L.D., Muir, W.A., Desnick, R.J., and Gaull, G.E.: Fetal tissue amino acid concentrations in argininosuccinic aciduria and in "maternal homocystinuria". Clin Chim Acta 94: 101-108, 1979.

Publication : 1979
Schacter, B., Muir, W.A., Gyves, M., Tasin, M.: HLA-A ,B compatibility in parents of offspring with neural defects or couples experiencing involuntary fetal wastage. Lancet 1:796-799, 1979.

Abstract : 1979
McLaren, G., Muir, W.A., Sachs, S., and Johnston, K.: Animal model for hemochromatosis: Hereditary susceptibility to hepatocellular iron overload. Presented at the Fourth International Conference on Proteins of Iron Metabolism, April 21, 1979, Davos, Switzerland.

Abstract : 1979
McLaren, G.D., Muir, W.A., Sachs, S.D., and Johnston, K.H.: Canine hemochromatosis: Hereditary susceptibility to hepatocellular iron overload in response to high lipid diet and thiouracil. Clin Res 27: 510A, 1979.

Abstract : 1979
McLaren, G.D., Boehm, C., and Muir, W.A.: Decreased uptake of iron by peripheral blood monocytes from patients with hereditary hemochromatosis. A clue to etiology? Blood 54 (Suppl. 1): 43a-, 1979.

Abstract : 1979
Goldsmith, G.H., Saito, H., and Muir, W.A.: Cold-labile anticoagulant in lymphoma. Blood 54 (Suppl 1): 280a, 1979.

Publication : 1979
Lubs, M.L., Conneally, P.M., Dumars, K.W., Greenstein, R.M., and Muir, W.A.: Carrier detection in Duchenne muscular dystrophy and its implications for genetic counseling.  In Genetic Diseases and Developmental Disabilities. Sadick, T.L., and Pueschel, S.M. (Eds.). AAS 1978 Symposium Series, Westview Press, Boulder, CO., 1979.

Abstract : 1978
McLaren, G.D., Griffin, J.P., and Muir, W.A.: Evidence for the multicellular origin of primary thrombocytosis. American Federation for Clinical Research, Mid-Western Regional Meeting, Chicago, Illinois, November 2, 1978. Clin Res 26: 669A, 1978.

Publication : 1978
McLaren, G.D., Doukas, M., and Muir, W.A.  Methyprylon-induced bone marrow suppression in siblings. An inherited defect? JAMA 240: 1744-1745, 1978.

Abstract : 1978
Harris, J.W., Farrell, D.E., Messer, M.J., Tripp, J., Brittenham, G.M., Danish, E.H., and Muir, W.A.:  Assessment of human  iron stores by magnetic susceptibility measurements: In vivo and in vitro studies. Meetings of The American Society for Clinical Investigation, San Francisco, April  30, 1978. Clin Res 26: 504A, 1978.

Abstract : 1978
Askari, A. D., Muir, W.A., McLaren, G.D., Braun, W., Moskowitz, R.W.: Arthritis as the presenting manifestation of hereditary hemochromatosis. Pan American Rheumatism Congress, Bogota, Columbia, June 19, 1973.

Abstract : 1978
McLaren, G.D., Muir, W.A., Braun, W.E., and Askari, A.D.: Hereditary hemochromatosis: Dominant inheritance and probable 1inkage to HLA. American College of Physicians, Ohio Regional Meeting, Columbus, Ohio, September 15, 1978.

Abstract : 1978
Muir, W.A., McLaren, G.D., Braun, W.E., and Askari, A.D.:  Hereditary hemochromatosis: Dominant inheritance and probable linkage to HLA. American Society of Human Genetics, 29th Annual Meeting, Vancouver, B.C., October 6, 1978. Am J Human Genet 30: 61A, 1978.

Abstract : 1978
Griffin, J.P., McLaren, G.D., and Muir, W.A.: Evidence for the multicellular origin of primary thrombocytosis. Blood 52 (Suppl 1): 162, 1978.

Abstract : 1977
Askari, A.D., Moskowitz, R.W., Muir, W.A.: Arthritis of hemochromatosis. Presented at the Ohio Regional Meeting of  the American College of Physicians, Cincinnati, Ohio, September 24, 1977.

Publication : 1977
Martin, A.O., Perrin, J.C.S., Muir, W.A., Ruch, E.,  and Schafer, I.A.: An autosomal dominant midline cleft syndrome resembling familial holoprosencephaly. Clin Genet  12: 65-72, 1977.


Abstract : 1977
Muir, W.A., McLaren, G.D., Braun, W.E.,s and Schacter, B.Z.:  HLA and the genetics of hemochromatosis, Clin Res 25: 573A, 1977.

Publication : 1977
Laborde, J.M., Green, D.L., Askari, A.D., and Muir, W.A.: Arthritis in Hemochromatosis: A Case Report. J Bone Joint Surg (AM)  59A: 1103-1107, 1977.


Publication : 1977
Kahn, M.A., Braun, W.E. , Kushner, I., Grecek, D.E., Muir, W.A., Steinberg, A.G.:  HLA-B27 in Ankylosing Spondylitis: Difference in Frequency and Relative Risk in American Blacks and Caucasians. J Rheum Suppl. No.3, 39-43, 1977.


Abstract : 1976
Goldsmith, G., Muir, W.A., and Agle, D.: Autoerythrocyte sensitization in a man with Ehlers-Danlos: Further evidence for the reliability of intracutaneous autologous blood injection in diagnosis. Clin Res 24: 309A, 1976.

Abstract : 1976
McLaren, Gordon D., Sachs, S.D., Muir, W.A., and Kellermeyer, R.W.: Canine hemochromatosis: A model for the study of reticuloendothelial cell function. Clin Res 24: 35A, 1976.

Abstract : 1976
McLaren, G.D., Tebbi, K., Muir, W.A.: Cytogenetic analysis of granulocyte colonies formed in vitro in chronic granulocytic leukemia. Abstracts, American Society of Hematology, 19th Annual Meeting, p. 151, 1976.

Publication : 1975
Ross, C., Muir, W.A., Ng, A.B.T., Graham, R.C., and Kellermeyer, R.W.: Hemochromatosis: Pathologic and Genetic Considerations. Am J Clin Pathol  63: 179-191, 1975.


Publication : 1974
Muir, W.A., and Ratnoff, O.D.: The Prevalence of PTA Deficiency. Blood44: 569-570, 1974.


Publication : 1974
Beutler, E., Sigalove, W., Muir, W.A., Matsumoto, F., and West, C.: Glucose-Phosphate-Isomerase (GPI) Deficiency: GPI Elyria. Ann Intern Md80: 730-732, 1974.


Publication : 1970
Steinberg, A.G., Muir, W.A., Rivat, Liliane, and Ropartz, C.: A pedigree demonstrating the transmission of a Gm 2, 8, 21 phenogroup.  Am J Hum Genet  22: 378-383, 1970.


Publication : 1968
Steinberg, A.G., Muir, W.A., and McIntire, S.A.: Two unusual Gm alleles: Their implications for the genetics of the Gm antigens. Am J Hum Genet20:258-278, 1968.


Publication : 1968
Slater, L.M., Muir, W.A., and Weed, R.I.: Influence of splenectomy on insoluble hemoglobin bodies in b-thalassemia erythrocytes. Blood  31: 766- 777, 1968.


Publication : 1967
Muir, W.A., and Steinberg, A.G.: On the genetics of the human allotypes Gm and Inv. Semin Hematol  4 : 156- 173, 1967.


Abstract : 1967
Steinberg, A.G., Muir, W. A., and McIntire, S.A.: A new allele at the Gm locus, Gm ( - / - ). Meetings of American Society of Human Genetics, Toronto, December, 1967.

Abstract : 1966
Weed, R.I., Slater, C., and Muir, W.A.: Inclusion bodies in b-thalassemia erythrocytes. Meetings of American Society of Hematology, New Orleans, December, 1966.