Class: Biological therapy
Generic Name: Carfilzomib
Trade Name: Kyprolis™

How is this drug used? Kyprolis is used to treat multiple myeloma that is worsening and that has previously been treated with Velcade® (bortezomib) and an immunomodulatory drug such as thalidomide or lenalidomide.

What is the mechanism of action? Kyprolis is a type of targeted drug known as a proteasome inhibitor. By interfering with certain signaling pathways within cells, Kyprolis reduces the growth and survival of cancer cells.

How is Kyprolis given (administered)? Kyprolis is given intravenously (into a vein).

How are patients monitored? Patients will usually have scheduled meetings with their healthcare provider while they are being treated with Kyprolis. Typically, blood will be drawn to check levels of blood cells and to monitor functions of some organ systems, such as the kidney and liver. Patients may also undergo physical examinations, scans or other measures to assess side effects and response to therapy.

What are the most common side effects of treatment with Kyprolis?

• Fatigue
• Anemia
• Nausea
• Low platelet levels
• Shortness of breath or difficulty breathing
• Diarrhea
• Fever

Kyprolis can cause serious problems with the heart, lungs, liver, or kidneys in some patients. Other side effects to watch for include infusion reactions and tumor lysis syndrome (a condition caused by the rapid breakdown of cancer cells; it can cause problems with the kidneys, heart, or other organs).

This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.

Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.

What can patients do to help alleviate or prevent discomfort and side effects?

• Pay careful attention to the physician’s instructions and inform the physician of any side effects.
• Maintain adequate rest and nutrition.
• Eat small meals frequently to help alleviate nausea.
• Avoid activities that may cause injury or bruising.

Are there any special precautions patients should be aware of before starting treatment?

• Patients should inform their physician about all medical conditions.
• Patients should inform their physician of any other medication or supplement they are taking (whether prescription or over-the-counter).
• Patients should inform their physician if they are pregnant, breastfeeding or planning a family in the near future. Kyprolis can harm an unborn baby.

When should patients notify their physician?

Tell your doctor if you experience any side effects that bother you or don’t go away. Also tell your doctor if you experience any of the following: fever, chills, chest pain, cough, swelling of the feet or legs, shortness of breath, dizziness, lightheadedness, or fainting.

What is a package insert?

A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.

Copyright © 2016 CancerConnect Last updated 08/12.

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